Premium
Studies on drug metabolism by use of isotopes XXIX—studies of the differences in biological fates of ephedrine isomers by use of a pseudo‐racemic mixture
Author(s) -
Baba Shigeo,
Kuroda Yumiko,
Horie Masanobu
Publication year - 1986
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200130309
Subject(s) - ephedrine , drug , drug metabolism , chemistry , metabolism , pharmacology , organic chemistry , biochemistry , medicine
Abstract The differences in metabolic fates of the optical isomers of ephedrine were investigated by use of a pseudo‐racemic mixture technique. In rats, the (—)‐isomer was more easily p ‐hydroxylated than the (+)‐isomer. A stereoselective reaction in the formation of the glucuronides of ephedrine, norephedrine and p ‐hydroxyephedrine was observed. The (—)‐isomers were more easily subjected to glucuronide formation than the (+)‐isomers. In human subjects, N ‐demethylation proved to be a steroselective reaction. It is also suspected that oxidative dealkylation of norephedrine is a stereoselective reaction.