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The use of capillary gas chromatography/mass spectrometry for the determination of acidic dopamine metabolites in human brain
Author(s) -
Michotte Yvette,
Deleu Dirk,
Ebinger Guy
Publication year - 1985
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200121206
Subject(s) - homovanillic acid , chemistry , chromatography , dopamine , mass spectrometry , 3,4 dihydroxyphenylacetic acid , gas chromatography–mass spectrometry , trimethylsilyl , gas chromatography , metabolite , capillary gas chromatography , organic chemistry , biochemistry , endocrinology , biology , serotonin , receptor
A capillary gas chromatographic/mass spectrometric method was developed for the determination of homovanillic acid and 3,4‐dihydroxyphenylacetic acid in discrete areas of human brain known to contain only small amounts of dopamine metabolites. The electron impact mass spectra of the trimethylsilyl derivatives of homovanillic acid and 3,4‐dihydroxyphenylacetic acid and their deuterated isotopic variants were used for their identification and quantification.