Premium
Analysis of non‐volatile nitrosamines by moving belt liquid chromatography/mass spectrometry
Author(s) -
Beattie Iain G.,
Games David E.,
Startin James R.,
Gilbert John
Publication year - 1985
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200121009
Subject(s) - chemistry , mass spectrometry , silylation , chromatography , vaporizer , ammonia , chemical ionization , decarboxylation , thermospray , nitrosamine , atmospheric pressure chemical ionization , organic chemistry , ionization , tandem mass spectrometry , selected reaction monitoring , catalysis , carcinogen , medicine , ion , pathology
Non‐volatile nitrosamines exemplified by nitroso amino acids, ‐dipeptides, ‐oxazolidines and ‐thiazolidines have been analysed by moving belt liquid chromatography/mass spectrometry (LC/MS) and spectra obtained by ammonia chemical ionization. Optimal conditions such as source temperature, source pressure and belt vaporizer temperature have been established. Interface degradation involving decarboxylation and denitrosation was experienced but could be alleviated to some extent by deactivation of the polyimide belt by silylation.