Premium
A revision of the metabolic disposition of amantadine
Author(s) -
Köppel Claus,
Tenczer Joachim
Publication year - 1985
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200120910
Subject(s) - amantadine , pharmacology , chemistry , urine , metabolite , metabolic pathway , metabolism , disposition , rimantadine , adamantane , medicine , biochemistry , virology , virus , influenza a virus , psychology , social psychology , organic chemistry
Amantadine is one of the most commonly used drugs for the control of tremor in Parkinson's disease. Additionally, it has an antiviral action in the prevention of type A influenza. It has been previously reported that amantadine is nearly completely eliminated in the urine. No metabolites have been detected. Surprisingly, in a case of amantadine overdose, several metabolites could be identified by gas chromatography/mass spectrometry. This finding prompted us to re‐investigate the metabolism of amantadine under a therapeutic dosing regimen. The bulk of the dose was eliminated unchanged. However, eight metabolites could be identified. Besides N‐acetylation which is the major metabolic pathway, several rather unusual metabolic pathways were observed: N‐methylation, formation of Schiff bases and N‐formiates. No metabolites with a hydroxylated adamantane ring system could be detected.