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The metabolism of tromantadine
Author(s) -
Köppel Claus,
Tenczer Joachim,
Rütten Elisabeth,
Klaschka Franz
Publication year - 1985
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200120909
Subject(s) - acetamide , chemistry , urine , metabolism , hydrochloride , chromatography , demethylation , metabolic pathway , organic chemistry , biochemistry , gene expression , dna methylation , gene
The metabolism of the antiviral drug tromantadine (1‐adamantyl‐2‐(2‐dimethylaminoethoxy)acetamide) was studied after an oral dose of 120 mg tromantadine hydrochloride using capillary gas chromatography/mass spectrometry. Most of the dose was excreted unchanged with the urine. Six metabolites could be identified. The main metabolic products were 1‐aminoadamantane (amantadine) and 1‐adamantyl‐(2‐hydroxy)acetamide. Further metabolic pathways were demethylation of the dimethylamino function and oxidative desamination to an unstable aldehyde which is oxidized to a carbonic acid or reduced to an alcohol.