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Electron impact induced fragmentations of the 1,4‐diene analogues of steroid hormones and related steroids
Author(s) -
Gonzalez Mario D.,
Burton Gerardo
Publication year - 1985
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200120809
Subject(s) - fragmentation (computing) , deuterium , steroid , diene , chemistry , electron ionization , labelling , hormone , ion , mass spectrum , stereochemistry , medicinal chemistry , organic chemistry , biology , biochemistry , ecology , physics , natural rubber , quantum mechanics , ionization
The electron impact induced fragmentations observed in the mass spectra of eight 1,4‐diene‐3‐ketopregnane steroids are described. The effect of hydroxyl substituents in positions 11β, 17α and 21, on the typical fragmentation pattern is analysed; in particular the ‘long range’ effect of the 17α‐hydroxy group on the relative abundance of the ions m /z 121 and 122 is confirmed using specific deuterium labelling.