The mass spectrometric analysis of the urinary metabolites of melatonin and its deuterated analogues, confirming their identity as  N ‐acetylserotonin and 6‐hydroxymelatonin | Zendy

Young I. M. | Zendy; Leone R. M. | Zendy; Silman R. E. | Zendy

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The mass spectrometric analysis of the urinary metabolites of melatonin and its deuterated analogues, confirming their identity as N ‐acetylserotonin and 6‐hydroxymelatonin

Author(s) -

Young I. M.,

Leone R. M.,

Silman R. E.

Publication year - 1985

Publication title -

biomedical mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0306-042X

DOI - 10.1002/bms.1200120704

Subject(s) - melatonin , metabolite , chemistry , deuterium , mass spectrometry , urine , chromatography , gas chromatography , biochemistry , endocrinology , biology , physics , quantum mechanics

In a recent study, we showed that melatonin could be metabolized to N ‐acetylserotonin and 6‐hydroxymelatonin. To confirm this finding rats were adminstered three different forms of deuterated melatonin intraperitoneally. Their urines were analysed by gas chromatography/mass spectrometry and the results showed, in each case, that the appropriate deuterated (or non‐deuterated) metabolite had been formed. From these data it is clear that N ‐acetylserotonin is a urinary metabolite of melatonin.

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