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Mass spectrometric fragmentation patterns for the Syn and Anti isomers of PGE 2 and PGD 2 ‐ methyloxime methyl esters and their analogs
Author(s) -
Hartzell Cynthia J.,
Andersen Niels H.
Publication year - 1985
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200120702
Subject(s) - fragmentation (computing) , chemistry , trimethylsilyl , ether , mass spectrometry , chromatography , stereochemistry , medicinal chemistry , organic chemistry , computer science , operating system
A systematic study of the mass spectral fragmentation of the methyl ester‐methyloxime‐trimethylsilyl ether derivatives of D and E prostaglandins and selected ω‐chain analogs is presented. Fragments from the ω‐chain analogs are shifted the appropriate mass when compared with the parent PGD 2 or PGE 2 . NMR data of the methyloxime methyl ester of PGE 2 have permitted assignment of the syn and anti isomers (relative to the α chain) to the fast and slow eluting gas chromatographic peaks, respectively.