Mass spectrometric fragmentation patterns for the  Syn  and  Anti  isomers of PGE 2  and PGD 2 ‐ methyloxime methyl esters and their analogs | Zendy

Hartzell Cynthia J. | Zendy; Andersen Niels H. | Zendy

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Mass spectrometric fragmentation patterns for the Syn and Anti isomers of PGE 2 and PGD 2 ‐ methyloxime methyl esters and their analogs

Author(s) -

Hartzell Cynthia J.,

Andersen Niels H.

Publication year - 1985

Publication title -

biomedical mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0306-042X

DOI - 10.1002/bms.1200120702

Subject(s) - fragmentation (computing) , chemistry , trimethylsilyl , ether , mass spectrometry , chromatography , stereochemistry , medicinal chemistry , organic chemistry , computer science , operating system

A systematic study of the mass spectral fragmentation of the methyl ester‐methyloxime‐trimethylsilyl ether derivatives of D and E prostaglandins and selected ω‐chain analogs is presented. Fragments from the ω‐chain analogs are shifted the appropriate mass when compared with the parent PGD 2 or PGE 2 . NMR data of the methyloxime methyl ester of PGE 2 have permitted assignment of the syn and anti isomers (relative to the α chain) to the fast and slow eluting gas chromatographic peaks, respectively.

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