Quantitative secondary ion monitoring gas chromatography/mass spectrometry of diethylstilbestrol in bovine liver | Zendy

Covey Thomas | Zendy; Maylin George | Zendy; Henion Jack | Zendy

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Quantitative secondary ion monitoring gas chromatography/mass spectrometry of diethylstilbestrol in bovine liver

Author(s) -

Covey Thomas,

Maylin George,

Henion Jack

Publication year - 1985

Publication title -

biomedical mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0306-042X

DOI - 10.1002/bms.1200120606

Subject(s) - chromatography , mass spectrometry , chemistry , selected ion monitoring , gas chromatography–mass spectrometry , diethylstilbestrol , gas chromatography , extraction (chemistry) , divinylbenzene , organic chemistry , hormone , styrene , biochemistry , copolymer , polymer

A procedure is described for the extraction of diethylstilbestrol (DES) from animal tissue for quantitative capillary gas chromatography/mass spectrometry (GC/MS). The procedure is based upon use of a strong anion exchange polystyrene divinylbenzene resin for sample purification. The recovery of DES from the resin clean up was 88% in the high parts per trillion (ppt) range. Criteria for identification of DES using selected ion monitoring (SIM) GC/MS are presented. Liquid chromatography/mass spectrometry (LC/MS) was used to investigate altered DES cis/trans ratios observed in biological extracts.

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