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Enhanced detection of drugs in complex mixtures by derivatization/secondary ion mass spectrometry
Author(s) -
Kidwell David A.,
Ross Mark M.,
Colton Richard J.
Publication year - 1985
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200120603
Subject(s) - derivatization , mass spectrometry , chemistry , tandem mass spectrometry , chromatography , secondary ion mass spectrometry , protein mass spectrometry , sample preparation in mass spectrometry , top down proteomics , selected reaction monitoring , ion mobility spectrometry–mass spectrometry , analytical chemistry (journal) , electrospray ionization
Derivatization/secondary ion (SI) mass spectrometry is a sensitive surface analysis technique. It can detect ppm levels of selected compounds in complex mixtures, as can tandem mass spectrometry. However, unlike tandem mass spectrometry it uses simpler instrumentation, since chemistry is used to select the compound of interest instead of a mass spectrometer. The application of derivatization/SI mass spectrometry is discussed regarding the analysis of drugs in aqueous media, tablets or human urine.