Comparison of gas chromatographic/mass spectrometric and microbiological assays for 5‐fluorouracil in plasma | Zendy

Min Bo H. | Zendy; Garland William A. | Zendy; Lewinson T. M. | Zendy; Mehta Bipin M. | Zendy

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Comparison of gas chromatographic/mass spectrometric and microbiological assays for 5‐fluorouracil in plasma

Author(s) -

Min Bo H.,

Garland William A.,

Lewinson T. M.,

Mehta Bipin M.

Publication year - 1985

Publication title -

biomedical mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0306-042X

DOI - 10.1002/bms.1200120510

Subject(s) - chromatography , chemistry , correlation coefficient , gas chromatography , mass spectrometry , fluorouracil , analytical chemistry (journal) , biology , mathematics , cancer , genetics , statistics

The concentrations of 5‐fluorouracil in 99 plasma samples were determined by both microbiological and gas chromatographic/mass spectrometric assays. The values determined by the two methods were similar (correlation coefficient = 0.90). A regression of the natural logarithms of the concentrations (0.01–94 μg ml −1 ) determined by the two methods gave a line whose slope and intercept were not statistically different (p>0.05) from 1 and 0 respectively. Thus, the microbiological assay has specificity over a sufficient concentration range to serve as a practical routine laboratory method for the determination of 5‐fluorouracil.

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