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Investigations on antipyrine metabolism V. Differentiation of two isomeric hydroxyantipyrine glucuronides by field desorption and fast atom bombardment mass spectrometry
Author(s) -
Lehmann W. D.,
Schiebel H. M.,
Böttcher J.,
Bässmann H.,
Schüppel R.
Publication year - 1985
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200120506
Subject(s) - fast atom bombardment , chemistry , desorption , fragmentation (computing) , mass spectrometry , glucuronide , field desorption , electron ionization , metabolism , analytical chemistry (journal) , chromatography , organic chemistry , biochemistry , adsorption , ionization , computer science , operating system , ion
The glucuronide conjugates of the two isomeric antipyrine phase I metabolites of antipyrine in man, 4‐hydroxyantipyrine and 3‐hydroxymethylantipyrine have been analysed by field desorption and fast atom bombardment mass spectrometry. These isomers could be clearly distinguished on the basis of their fragmentation behaviour which was found to correlate with that observed under pyrolysis electron impact conditions.