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Matrix enhanced laser desorption in mass spectrometry and tandem mass spectrometry
Author(s) -
Wright Larry G.,
Cooks R. G.,
Wood Karl V.
Publication year - 1985
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200120404
Subject(s) - chemistry , mass spectrometry , desorption , dissociation (chemistry) , tandem mass spectrometry , alkali metal , collision induced dissociation , ion , selectivity , yield (engineering) , matrix (chemical analysis) , analytical chemistry (journal) , laser , photochemistry , organic chemistry , chromatography , materials science , catalysis , adsorption , physics , optics , metallurgy
When sampled by laser irradiation from a suitable matrix, cationized sugars can be desorbed in far higher yields for longer periods than in experiments which do not employ a matrix. Daughter spectra reveal that Li + reacts differently from the other alkali ions in that it can catalyse ring opening; collision‐induced dissociation then causes successive CC cleavage reactions. Selectivity is also exhibited by the substrate; some isomers yield much more intense ion currents with the alkali metals than do others. These findings should contribute to a wider use of laser desorption, including selective examination of mixtures for particular types of compounds, as well as detailed structural studies on individual substances.