A comparison of thermospray and direct liquid introduction high‐performance liquid chromatography/mass spectrometry for the analysis of candidate antimalarials | Zendy

Voyksner Robert D. | Zendy; Bursey Joan T. | Zendy; Hines John W. | Zendy; Pellizzari Edo D. | Zendy

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A comparison of thermospray and direct liquid introduction high‐performance liquid chromatography/mass spectrometry for the analysis of candidate antimalarials

Author(s) -

Voyksner Robert D.,

Bursey Joan T.,

Hines John W.,

Pellizzari Edo D.

Publication year - 1984

Publication title -

biomedical mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0306-042X

DOI - 10.1002/bms.1200111205

Subject(s) - thermospray , chromatography , mass spectrometry , high performance liquid chromatography , chemistry , detection limit , analytical chemistry (journal) , liquid chromatography–mass spectrometry , tandem mass spectrometry , selected reaction monitoring

The analysis of antimalarials by high‐performance liquid chromatography (HPLC)/mass spectrometry demonstrates a new dimension in specificity along with increased sensitivity compared to conventional HPLC detection methods. Both direct liquid introduction and thermospray HPLC/mass spectrometry interfaces provided molecular weight information as well as characteristic fragment ions for antimalarials not normally amenable to direct probe or gas chromatographic/mass spectrometric techniques. The direct liquid introduction interface, which incorporated a 1/100 split, showed a detection limit of 30 ng using selected ion monitoring. The thermospray technique showed less than 1 ng detection limits using selected ion monitoring.

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