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Mass spectral and HPLC analysis of biological compounds with diphenylborinic acid
Author(s) -
Flückiger Rudolf,
Henson Edward,
Hess Guido M.,
Gallop Paul M.
Publication year - 1984
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200111204
Subject(s) - mass spectrometry , chemistry , high performance liquid chromatography , adduct , spectral analysis , amino acid , molecule , chromatography , amino acid analysis , organic chemistry , combinatorial chemistry , biochemistry , spectroscopy , physics , quantum mechanics
Diphenylborinic acid is shown to react with a variety of polyfunctional molecules of biological interest to give products which are easily identifiable by mass spectrometry. The diphenylborinate adducts of amino acids possess extraordinary stability and are separable by reverse phase chromatography. The stability of products is discussed with regard to the nature and stereochemical arrangement of the functional groups involved in complex formation.