A stable isotope method for the quantification of  N ‐acetyl‐5‐aminosalicylic acid in plasma and urine | Zendy

Fischer C. | Zendy; Meese C. O. | Zendy; Klotz U. | Zendy

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A stable isotope method for the quantification of N ‐acetyl‐5‐aminosalicylic acid in plasma and urine

Author(s) -

Fischer C.,

Meese C. O.,

Klotz U.

Publication year - 1984

Publication title -

biomedical mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0306-042X

DOI - 10.1002/bms.1200111009

Subject(s) - chemistry , urine , metabolite , aminosalicylic acid , acetylation , chromatography , in vivo , deuterium , biochemistry , pharmacology , biology , physics , microbiology and biotechnology , quantum mechanics , gene

The synthesis of a number of N ‐acyl‐5‐aminosalicylic acids and their derivatives is described. These compounds allow the sensitive and specific mass spectrometric determination of unlabelled or deuterium‐labelled N ‐acetyl‐5‐aminosalicylic acid in biological samples. An in vivo study shows that the labelled compound, administered to rats, is excreted isotopically unchanged to at least 97%, and that no significant deacety lation/acetylation mechanism exists for this metabolite N ‐acetyl‐5‐aminosalicylic acid of salicylazosulphapyridine.

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