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Gas phase electron ionization fragmentation of dextromethorphan and related quaternary ammonium salts
Author(s) -
Wainer Irving W.,
Ohashi Mamoru,
Barron Robert P.,
Benson Walter
Publication year - 1984
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200111007
Subject(s) - fragmentation (computing) , mass spectrum , electron ionization , ion , ionization , ammonium , chemistry , dextromethorphan , chemical ionization , mass spectrometry , thermal stability , analytical chemistry (journal) , organic chemistry , chromatography , computer science , operating system , medicine , anesthesia
Abstract The in‐beam electron ionization (EI) spectra of quaternary ammonium salts of dextromethorphan and piperidine consist of peaks arising both from thermal degradation products and from the fragmentation of the molecular cation [R 4 N] + . Mass‐analysed ion kinetic energy and ion kinetic energy spectra indicate that several major ions believed to be thermally induced before EI are also produced directly from [R 4 N] + fragmentation. However, the contribution of the direct fragmentation of [R 4 N] + upon EI is small in comparison to that of the thermal degradation products. This behavior was observed in the conformationally flexible and rigid piperidinium rings studied.