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A gas chromatographic/mass spectrometric assay for flutroline, a γ‐carboline antipsychotic agent, with direct derivatization on a moving needle injector
Author(s) -
Falkner Fred C.,
Fouda Hassan G.,
Mullins Francis G.
Publication year - 1984
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200110909
Subject(s) - derivatization , chromatography , chemistry , injector , derivative (finance) , gas chromatography , capillary gas chromatography , pharmacokinetics , antipsychotic drug , mass spectrometry , gas chromatography–mass spectrometry , antipsychotic , pharmacology , schizophrenia (object oriented programming) , mechanical engineering , medicine , financial economics , engineering , economics , computer science , programming language
A method has been developed for the determination of flutroline in plasma using capillary gas chromatography and selected ion monitoring detection of the TMS derivative. The method is linear over the concentration range of 3–60 ng ml −1 and was used to define the drug pharmacokinetics and bioavailability in animals and man. A novel method for direct derivatization on the tip of a moving needle injector is described.