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Mass spectral identification of benzothiazole derivatives leached into injections by disposable syringes
Author(s) -
Salmona G.,
Assaf A.,
GayteSorbier A.,
Airaudo Ch. B.
Publication year - 1984
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200110903
Subject(s) - benzothiazole , vulcanization , chemistry , mass spectrometry , leaching (pedology) , sterilization (economics) , ethylene oxide , derivative (finance) , nuclear chemistry , natural rubber , radiochemistry , organic chemistry , chromatography , polymer , environmental science , copolymer , soil science , monetary economics , economics , foreign exchange market , soil water , foreign exchange , financial economics
Five benzothiazole derivatives leached into injections by the rubber plunger‐seals of disposable syringes were identified by electron impact (EI) and chemical ionization (CI) mass spectrometry. These are 2‐hydroxybenzothiazole, 2‐mercaptobenzothiazole, 2‐(methylmercaptopto)benzothiazole, 2‐(2‐hydroxyethoxy)benzothiazole and 2‐(2‐hydroxyethylmercapto)benzothiazole. 2‐Mercaptobenzothiazole is used as a vulcanization accelerator. The other four compounds are formed from the zinc derivative of 2‐mercaptobenzothiazole during sterilization with ethylene oxide. Toxicological, technological and legal consequences of the leaching are discussed briefly.