Conffirmatory assay for ivermectin in cattle tissue using chemical ionization mass spectrometry/mass spectrometry (MS/MS) | Zendy

Tway P. C. | Zendy; Dddowning G. V. | Zendy; Slayback J. R. B. | Zendy; Rahn G. S. | Zendy; Isersee R. K. | Zendy

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Conffirmatory assay for ivermectin in cattle tissue using chemical ionization mass spectrometry/mass spectrometry (MS/MS)

Author(s) -

Tway P. C.,

Dddowning G. V.,

Slayback J. R. B.,

Rahn G. S.,

Isersee R. K.

Publication year - 1984

Publication title -

biomedical mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0306-042X

DOI - 10.1002/bms.1200110407

Subject(s) - mass spectrometry , ivermectin , chemistry , atmospheric pressure chemical ionization , mass spectrometry imaging , chromatography , ion mobility spectrometry–mass spectrometry , thermal ionization mass spectrometry , chemical ionization , ionization , selected reaction monitoring , tandem mass spectrometry , biology , ion , organic chemistry , zoology

A method based on direct exposure, positive ion, chemical ionization mass spectrometry/mass spectrometry (ms/ms) was developed for the confirmatory assay of the antiparasitic drug, ivermectin, in animal tissue. Following extraction, column and preparative liquid chromatography, mass spectrometric/mass spectrometric analysis of the drug in liver samples provided reliable detection limits to 8–10 parts‐par‐billion at a signal: noise of greater than 10:1. Blank tissue consistently displayed no chemical/matrix interference. Besides the development of a confirmatory assay, the study also demonstrates the analytical capabaility and the role of MS/MS vis‐a‐vis other applied mass spectrometric techniques.

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