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Mass spectrometric identification of abnormal aromatic compounds in the urine of a child with Reye's like syndrome
Author(s) -
Rocchiccioli F.,
Cartier P. H.,
Bougnères P. F.
Publication year - 1984
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200110307
Subject(s) - reye syndrome , urine , chemistry , gas chromatography–mass spectrometry , reye's syndrome , chromatography , organic chemistry , mass spectrometry , biochemistry , medicine
The urine of a young child with hypoglycemia and a Reye's like syndrome contained an excess of unusual aromatic products with a three carbon chain, phenylpropionylglycine and 3‐ and 4‐(hydroxyphenyl)propionic and 3‐(3‐methoxy‐4‐hydroxyphenyl)propionic acids, as well as of organic acids usually found in fatty acid β‐oxidation defects: the mono‐ and dicarboxylic acids derived from the respective (ω – 1) and ω‐oxidation of C 6 to C 10 fatty acids.