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Field desorption mass spectrometry of anthracyclines comparison with other soft ionization techniques
Author(s) -
Gioia B.,
Arlandini E.,
Vigevani A.
Publication year - 1984
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200110107
Subject(s) - field desorption , fast atom bombardment , chemistry , mass spectrometry , ion , ionization , desorption , chemical ionization , fragmentation (computing) , ion source , soft laser desorption , analytical chemistry (journal) , mass spectrum , thermal ionization , electron ionization , matrix assisted laser desorption/ionization , chromatography , adsorption , organic chemistry , computer science , operating system
Field desorption mass spectral data relative to 38 anthracycline derivatives are presented. A molecular ion, or [MH] + ion is always present; in most cases it is the base peak in the spectrum at the best anode temperature. Increase in the emitter temperature promotes fragmentation which gives useful structural information. A comparison has been made between field desorption and other soft ionization techniques such as fast atom bombardment, desorption chemical ionization and a liquid chromatographic mass spectrometric interface with direct liquid introduction into a chemical ionization ion source. The most significant results were obtained by using positive and negative ion fast atom bombardment and direct liquid introduction with negative ion detection.