Metabolism of the anticancer agent 1‐(4‐acetylphenyl)‐3,3‐dimethyltriazene | Zendy

Farina P. | Zendy; Benfenati E. | Zendy; Reginato R. | Zendy; Torti L. | Zendy; D'Incalci M. | Zendy; Threadgill M. D. | Zendy; Gescher A. | Zendy

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Metabolism of the anticancer agent 1‐(4‐acetylphenyl)‐3,3‐dimethyltriazene

Author(s) -

Farina P.,

Benfenati E.,

Reginato R.,

Torti L.,

D'Incalci M.,

Threadgill M. D.,

Gescher A.

Publication year - 1983

Publication title -

biomedical mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0306-042X

DOI - 10.1002/bms.1200100808

Subject(s) - chemistry , metabolite , metabolism , mass spectrometry , stereochemistry , in vitro , drug metabolism , chromatography , biochemistry

High pressure liquid chromatography was used in combination with mass spectrometry to confirm that the main products of in vitro metabolism of 1‐(4‐acetylphenyl)‐3,3‐dimethyltriazene are 1‐(4‐acetylphenyl‐3‐methyltriazene and 4‐aminoacetophenone. In addition a novel metabolite, 1‐[4‐(1‐hydroxyethyl)‐phenyl]‐3,3‐dimethyltriazene, possessing antitumour activity similar to the parent drug, was identified.

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