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Metabolism of the anticancer agent 1‐(4‐acetylphenyl)‐3,3‐dimethyltriazene
Author(s) -
Farina P.,
Benfenati E.,
Reginato R.,
Torti L.,
D'Incalci M.,
Threadgill M. D.,
Gescher A.
Publication year - 1983
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200100808
Subject(s) - chemistry , metabolite , metabolism , mass spectrometry , stereochemistry , in vitro , drug metabolism , chromatography , biochemistry
High pressure liquid chromatography was used in combination with mass spectrometry to confirm that the main products of in vitro metabolism of 1‐(4‐acetylphenyl)‐3,3‐dimethyltriazene are 1‐(4‐acetylphenyl‐3‐methyltriazene and 4‐aminoacetophenone. In addition a novel metabolite, 1‐[4‐(1‐hydroxyethyl)‐phenyl]‐3,3‐dimethyltriazene, possessing antitumour activity similar to the parent drug, was identified.