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Analysis of N 4 ‐trideuteroacetylsulphamerazine and its metabolites sulphamerazine and N 4 ‐acetylsulphamerazine in man by means of high‐performance liquid chromatography and mass spectrometry
Author(s) -
Vree Tom B.,
Tijhuis Marian W.,
Baakman Margriet,
Hekster Chiel A.
Publication year - 1983
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200100303
Subject(s) - chromatography , mass spectrometry , high performance liquid chromatography , chemistry , liquid chromatography–mass spectrometry
The synthesis, high‐performance liquid chromatographic and mass spectrometric analysis of N 4 ‐trideuteroacetylsulphamerazine is described. N 4 ‐trideuteroacetylsulphamerazine in man is deacetylated into sulphamerazine, which in turn is acetylated again into N 4 ‐acetylsulphamerazine. The existence of a deacetylationacetylation equilibrium in man has been demonstrated.