Analysis of N 4 ‐trideuteroacetylsulphamerazine and its metabolites sulphamerazine and N 4 ‐acetylsulphamerazine in man by means of high‐performance liquid chromatography and mass spectrometry | Zendy

Vree Tom B. | Zendy; Tijhuis Marian W. | Zendy; Baakman Margriet | Zendy; Hekster Chiel A. | Zendy

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Analysis of N 4 ‐trideuteroacetylsulphamerazine and its metabolites sulphamerazine and N 4 ‐acetylsulphamerazine in man by means of high‐performance liquid chromatography and mass spectrometry

Author(s) -

Vree Tom B.,

Tijhuis Marian W.,

Baakman Margriet,

Hekster Chiel A.

Publication year - 1983

Publication title -

biomedical mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0306-042X

DOI - 10.1002/bms.1200100303

Subject(s) - chromatography , mass spectrometry , high performance liquid chromatography , chemistry , liquid chromatography–mass spectrometry

The synthesis, high‐performance liquid chromatographic and mass spectrometric analysis of N 4 ‐trideuteroacetylsulphamerazine is described. N 4 ‐trideuteroacetylsulphamerazine in man is deacetylated into sulphamerazine, which in turn is acetylated again into N 4 ‐acetylsulphamerazine. The existence of a deacetylationacetylation equilibrium in man has been demonstrated.

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