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Identification of fendiline metabolites in human urine
Author(s) -
Benthe H. F.,
Thieme R. A.
Publication year - 1983
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200100204
Subject(s) - glucuronidation , urine , hydroxylation , chemistry , sulfation , glucuronide , biochemistry , microsome , enzyme
After oral application of 14 C labelled fendiline, 13 metabolites of this drug could be identified in human urine. Only traces of parent fendiline were excreted in the urine. The main pathway of metabolism is hydroxylation of phenyl groups with subsequent glucuronidation and sulphation. On the other hand, oxidative dealkylation occurs with the amino group remaining at the 3,3‐diphenylpropyl moiety and p‐hydroxyacetophenone being formed almost entirely from the 1‐phenylethyl group.