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Synthesis and utility of deuterium labeled trimethylanilinium hydroxide in the mass spectral analysis of nucleosides
Author(s) -
Teece Robert G.,
Slowikowski Deborah,
Schram Karl H.
Publication year - 1983
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200100107
Subject(s) - deuterium , reagent , chemistry , hydroxide , organic chemistry , chromatography , nuclear physics , physics
A simple preparation for the synthesis of ( 2 H 9 )trimethylanilinium hydroxide is detailed. The utility of this deuterated ‘on column’ permethylation reagent for the preparation of volatile derivatives of nucleosides for gas chromatographic mass spectrometric analysis is described.