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Simultaneous determination of terbutaline and salbutamol in plasma by selected ion monitoring
Author(s) -
Lindberg Claes,
Jönsson Sven
Publication year - 1982
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200091107
Subject(s) - terbutaline , salbutamol , chromatography , chemistry , mass spectrometry , coefficient of variation , plasma , deuterium , medicine , asthma , physics , quantum mechanics
We describe a method for simultaneous determination of terbutaline and salbutamol in plasma, based on gas chromatography chemical ionization mass spectrometry. Deuterium labelled terbutaline was used as internal standard for both drugs. The method has been used for the analysis of plasma samples obtained from asthmatic patients. The coefficient of variation at 0.3 ng ml −1 was 4.6% for terbutaline and 5.3% for salbutamol with a sample volume of 4 ml. The recovery of both drugs was >80%.