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Simultaneous determination of antipyrine, 4‐ hydroxyantipyrine, 3‐hydroxymethylantipyrine and norantipyrine in urine by gas chromatography chemical ionization mass spectrometry
Author(s) -
Tang B. K.,
Uchino H.,
Inaba T.,
Kalow W.
Publication year - 1982
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200091004
Subject(s) - chemistry , chromatography , urine , mass spectrometry , gas chromatography , chemical ionization , gas chromatography–mass spectrometry , deuterium , ionization , organic chemistry , biochemistry , ion , physics , quantum mechanics
A simple, accurate and precise procedure was developed to quantify, in a single run, antipyrine, 4‐hydroxyantipyrine, 3‐hydroxymethylantipyrine and norantipyrine in urine. The stable isotope‐labelled internal standards for the assay were obtained from a subject who ingested deuterium labelled antipyrine and produced urine containing the labelled drug and metabolites.