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Identification of 4,6‐dioxoheptanoic acid (succinylacetone), 3,5‐dioxooctanedioic acid (succinylacetoacetate) and 4‐oxo‐6‐ hydroxyheptanoic acid in the urine from patients with hereditary tyrosinemia
Author(s) -
Lindblad Bengt,
Steen Göran
Publication year - 1982
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200091003
Subject(s) - tyrosinemia , urine , chemistry , chromatography , mass spectrometry , biochemistry , tyrosine
In the urine from patients with hereditary tyrosinemia, three characteristic compounds have been found. They have been identified as 4,6‐dioxoheptanoic acid (succinylacetone), 3,5‐dioxooctanedioic acid (succinyl‐acetoacetate) and 4‐oxo‐6‐hydroxyheptanoic acid. The identities have been established by mass spectrometry of several derivatives, and by comparison with a synthetic sample of 4,6‐dioxoheptanoic acid.