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Mass spectra of the trimethylsilyl ethers of some 3β‐hydroxy‐Δ 5 ‐C 21 steroids
Author(s) -
Harvey D. J.,
Middleditch B. S.,
Brooks C. J. W.
Publication year - 1982
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200091002
Subject(s) - fragmentation (computing) , trimethylsilyl , mass spectrum , ion , chemistry , hydroxylation , labelling , spectral line , mass spectrometry , polyatomic ion , medicinal chemistry , stereochemistry , organic chemistry , chromatography , physics , biochemistry , enzyme , astronomy , computer science , operating system
The mass spectra of the trimethylsilyl derivatives of 22 3β‐hydroxy‐Δ 5 ‐pregnenes have been examined with the aid of deuterlum labelling and high resolution mass measurements. The influence of additional hydroxy and keto substituents on the characteristic fragment ions is discussed and fragmentation mechanisms for several ions characteristic of hydroxylation at specific sites (11 and 16) are proposed.