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The application of stable isotopes in biomedical research
Author(s) -
Haskins N. J.
Publication year - 1982
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200090702
Subject(s) - stable isotope ratio , isotope , identification (biology) , computer science , computational biology , biology , nuclear physics , physics , ecology
Many of the ways in which stable isotopes are used in biomedical research are reviewed. The use of stable isotopes in stable isotope dilution assay, for metabolite identification and in pharmacokinetic studies, is discussed and relevant examples are given to illustrate the various points made. Isotope effects and their implications for future drug design are considered. Some of the toxicity problems associated with the use of stable isotopes are also considered. Finally, a brief subjective view of possible future advances is made.