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The use of gas chromatography mass spectrometry in the evaluation of the synthesis of 3‐dimethylaminomethyl‐2‐(3′, 4′‐dichlorophenyl)bicyclo[2.2.2.] octane. A novel drug with potential antidepressant activity
Author(s) -
Mallen David N. B.,
Smith Julie M.
Publication year - 1982
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200090310
Subject(s) - octane , chemistry , bicyclic molecule , mass spectrometry , gas chromatography–mass spectrometry , gas chromatography , drug , chromatography , stereochemistry , organic chemistry , pharmacology , medicine
Gas chromatography mass spectrometry was used to characterize compounds observed throughout the synthesis of a cis ‐fused 3′,4′‐dichlorophenyl bicyclo‐octane, a potential CNS acting drug substance. An ortho chloro‐effect identified the isomeric 2′,4′‐dichlorophenyl impurities.