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The mass spectra of the trimethylsilyl derivatives of the hydroxy and acid metabolites of Δ 1 ‐ and Δ 6 ‐tetrahydrocannabinol
Author(s) -
Harvey D. J.
Publication year - 1981
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200081205
Subject(s) - trimethylsilyl , mass spectrum , chemistry , tetrahydrocannabinol , fragmentation (computing) , labelling , mass spectrometry , ion , deuterium , chromatography , stereochemistry , medicinal chemistry , organic chemistry , cannabinoid , biochemistry , biology , ecology , physics , receptor , quantum mechanics
Deuterium labelling and high resolution mass measurements have been used to investigate the fragmentation mechanisms leading to diagnostic ions in the mass spectra of the trimethylsilyl derivatives of 58 hydroxy and acid metabolites of Δ 1 ‐ and Δ 6 ‐tetrahydrocannabinol and of two related compounds, 2α‐ and 2β‐hydroxy‐Δ 6 ‐tetrahydrocannabinol. The spectra of most of the hydroxy metabolites contained abundant ions which were characteristic of the position of hydroxy substitution. These could be used diagnostically to determine the structures of polysubstituted metabolites.