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Using 7‐chlor‐4‐nitrobenzo‐2‐oxa‐1,3‐diazole for mass spectrometric and gas. Chromatographic mass spectrometric analysis of N ‐nitrosamines in environmental samples
Author(s) -
Kostyukovskii Yakov L.,
Medvedev Felix A.,
Melamed David B.
Publication year - 1981
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200081003
Subject(s) - chemistry , chromatography , detection limit , nitrosamine , relative standard deviation , gas chromatography , mass spectrometry , quantitative analysis (chemistry) , gas chromatography–mass spectrometry , carcinogen , organic chemistry
A mass spectrometric method for quantitative determination of volatile N ‐nitrosamines, based on analysis of the derivatives formed from secondary amines produced by denitrosation of N ‐nitrosamines when they are reacted with 7‐chlor‐4‐nitrobenzo‐2‐oxa‐1,3‐diazole, is proposed. The method has been applied to the quantitative analysis of 3‐4 component mixtures of N ‐nitrosamines without preliminary separation. The detection limit was 1 ng with a relative standard deviation of 0.13–0.25. A gas chromatographic mass spectrometric method for the identification and quantification of multicomponent mixtures of N ‐nitrosamines was also developed with a detection limit of 1 ng μ1 −1 and relative standard deviation of 0.11–0.22. These methods are recommended for N ‐nitrosamine determination in environmental samples and have the advantage that the standards can be prepared not from carcinogenic N ‐nitrosamines, but directly from the respective secondary amines.