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252 Californium plasma desorption mass spectrometry
Author(s) -
Macfarlane Ronald D.
Publication year - 1981
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200080918
Subject(s) - mass spectrometry , chemistry , desorption , analytical chemistry (journal) , static secondary ion mass spectrometry , molecule , inductively coupled plasma mass spectrometry , thermal ionization mass spectrometry , ion , dart ion source , sample preparation in mass spectrometry , sample preparation , ionization , chromatography , secondary ion mass spectrometry , electron ionization , organic chemistry , electrospray ionization , adsorption
The mass spectrometry of involatile molecules presents problems not encountered when the molecule can be volatilized and subsequently ionized in the gas phase. The production of ions from a condensed phase is sensitively dependent on the properties of the matrix. The presence of impurities in the sample can totally quench molecular ion formation even though the sample contains a high percentage of the molecule of interest. One of the methods used for the mass spectrometry of involatile molecules is 252 Californium plasma desorption mass spectrometry. The basic principles of this method will be presented with examples of its application that include the identification of involatile marine toxins (including the red tide toxins). We shall also introduce a new variation in mass spectrometry, a study of time‐dependent effects, a technique that can be used to follow dynamic changes as a result of chemical reactions occurring in the sample at room temperature. This is possible in 252 Californium plasma desorption mass spectrometry because the sample is conserved during the analysis.