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Identification of minor metabolites of 5‐fluorocytosine in man by chemical ionization gas chromatography mass spectrometry
Author(s) -
Williams K. M.,
Duffield A. M.,
Christopher R. K.,
Finlayson P. J.
Publication year - 1981
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200080410
Subject(s) - metabolite , urine , chemistry , chromatography , mass spectrometry , drug , urinary system , gas chromatography , pharmacology , chemical ionization , medicine , biochemistry , ionization , organic chemistry , ion
A new minor metabolite of 5‐fluorocytosine, 6‐hydroxy‐5‐fluorocytosine, was found in the urinary gravel excreted by a patient being treated with this drug. A metabolite of 5‐fluorocytosine in animals, α‐fluoro‐β‐alanine, was identified and quantitated in the urine of nine patients. In general, α‐fluoro‐β‐alanine represented 0.05‐0.25% of the daily dose of 5‐fluorocytosine, both for orally and intravenously administered drug. Minor metabolites have been implicated in the occasional toxicity observed in patients receiving 5‐fluorocytosine.