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Gas chromatography mass spectrometry of androstanolones as methyl oxime, tert ‐butyldimethylsilyl ether derivatives
Author(s) -
Gaskell Simon J.,
Pike Adrian W.
Publication year - 1981
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200080309
Subject(s) - oxime , fragmentation (computing) , chemistry , electron ionization , mass spectrometry , chromatography , selected ion monitoring , ether , high resolution , gas chromatography , resolution (logic) , medicinal chemistry , gas chromatography–mass spectrometry , ion , stereochemistry , organic chemistry , biology , ecology , remote sensing , artificial intelligence , computer science , ionization , geology
The fragmentation of the methyl oxime, tert ‐butyldimethylsilyl derivatives of androstanolones under electron impact is strongly directed by the derivatized functional groups. The relative importance of the few major fragmentation pathways varies between positional isomers and stereoisomers. High resolution selected ion monitoring of [M—C 4 H 9 ] + , and metastable peak monitoring of [M—C 4 H 9 ] + → [M—C 4 H 9 —H(CH 3 ) 2 SiOH] + , may both be used for high sensitivity analysis.