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Positive and negative ion desorption chemical ionization of some penicillins
Author(s) -
Gower John L.,
Beaugrand Claude,
Sallot Claude
Publication year - 1981
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200080109
Subject(s) - chemical ionization , desorption , chemistry , ion , fragmentation (computing) , mass spectrum , electron ionization , ionization , analytical chemistry (journal) , mass spectrometry , soft laser desorption , ion source , ambient ionization , chromatography , matrix assisted laser desorption/ionization , adsorption , organic chemistry , computer science , operating system
The ammonia positive ion desorption chemical ionization and methane negative ion desorption chemical ionization mass spectra of five commercially available penicillins have been studied. In every case ions characteristic of the molecular weight were obtained together with diagnostically significant fragment ions. As well as the known fragmentation pathways observed under electron impact conditions a significantly different fragmentation pathway was observed using negative ion desorption ionization. The reproducibility of the spectra obtained contrasts markedly with previous reports on the mass spectra of penicillin free acids.