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A new metabolite of propachlor isolated from germfree rat excreta
Author(s) -
Feil V. J.,
Bakke J. E.,
Larsen G. L.,
Gustafsson B. E.
Publication year - 1981
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200080102
Subject(s) - metabolite , sulfoxide , chemistry , artifact (error) , mass spectrometry , chromatography , cysteine , biochemistry , organic chemistry , biology , enzyme , neuroscience
2‐[ S ‐( N ‐Acetyl)cysteine]‐isopropylacetanilide sulfoxide was isolated from the exrcreta of germfree rats given oral doses of 2‐chloro‐ N ‐isopropylacetanilide. The metabolite was characterized by mass and nuclear magnetic resonance spectrometry on samples isolated from rats dosed with [1‐ 14 C]‐ and [2‐ 13 C]‐2‐chloro‐ N ‐isopropylacetanilide. Artifact formation upon reaction of the sulfoxide with alcoholic HCl is discussed.