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The use of stable isotopes to prove the saturable first‐pass effect of methoxsalen
Author(s) -
Schmid Jochen,
Prox Axel,
Zipp Horst,
Koss F. W.
Publication year - 1980
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200071123
Subject(s) - methoxsalen , chemistry , linearity , isotope , first pass , nuclear physics , mathematics , physics , medicine , quantum mechanics , dermatology , psoriasis , arithmetic
Methoxsalen, administered orally shows a strong, albeit saturable first‐pass effect, as demonstrated by classical dose linearity testing and by a new method, using stable isotopes and gas chromatographic mass spectrometric analysis. The therapeutic consequences of the first‐pass effect are discussed.