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Studies on anabolic steroids. The mass spectra of 17α‐methyl‐17β‐hydroxy‐1,4‐androstadien‐3‐one (dianabol) and its metabolites
Author(s) -
Dürbeck Hans Werner,
Büker Ingrid
Publication year - 1980
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200071007
Subject(s) - chemistry , mass spectrum , chromatography , urine , fragmentation (computing) , mass spectrometry , anabolism , gas chromatography–mass spectrometry , gas chromatography , metabolism , biochemistry , biology , ecology
The metabolism of 17α‐methyl‐17β‐hydroxy‐1,4‐androstadien‐3‐one (dianabol) in human adults has been studied in detail by computer aided capillary gas chromatography mass spectrometry. After oral administration to man six metabolites were determined in the free fraction of the urine samples, the structures of which have been identified as 17‐epidianabol, three isomers of 6‐hydroxydianabol, 17α‐methyl‐17β‐hydroxy‐1,4,6‐androstatrien‐3‐one (Δ 6 ‐dianabol) and 18‐nor‐17,17‐dimethyl‐1,4,13(14)‐androstatrien‐3‐one, respectively. In agreement with previous observations no measurable amounts of the administered drug itself could be detected in any of the urine samples investigated. The mass spectra of all metabolites and the main fragmentation processes are discussed in detail.