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Mass spectra of new 5‐fluorouracil derivatives: Antitumor agents
Author(s) -
Marunaka Teruyoshi,
Umeno Yukihiko,
Minami Yoshinori,
Shibata Toshiaki
Publication year - 1980
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200070804
Subject(s) - chemistry , mass spectrum , fluorouracil , electron ionization , mass spectrometry , ion , tetrahydrofuran , decomposition , ionization , substituent , spectral line , medicinal chemistry , organic chemistry , chemotherapy , chromatography , physics , medicine , surgery , solvent , astronomy
The mass spectra of 1, 3‐bis(tetrahydro‐2‐furanyl)‐5‐fluorouracil, 1‐(tetrahydro‐2‐furanyl)‐5‐fluorouracil and 3‐(tetrahydro‐2‐furanyl)‐5‐fluorouracil, which are new 5‐fluorouracil derivatives with strong antitumor activity, were measured by field desorption, chemical ionization and electron impact methods. In the electron impact mass spectra of 1‐ and 3‐(tetrahydro‐2‐furanyl)‐5‐fluorouracil, which differ in the position of the tetrahydrofuran substituent on the 5‐fluorouracil skeleton, and in the spectra of their methyl derivatives, the characteristic patterns of fragment ions formed by the retro Diels‐Alder decomposition provided useful information for determination of the structures of these compounds.