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Determination of apomorphine in plasma by selected ion monitoring
Author(s) -
Watanabe Hirokazu,
Nakano Shigeyuki,
Ogawa Nobuya,
Suzuki Tokiko
Publication year - 1980
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200070405
Subject(s) - apomorphine , chemistry , chromatography , ion , pharmacokinetics , pharmacology , biochemistry , receptor , medicine , agonist , organic chemistry
A selected ion monitoring assay for apomorphine using N‐n ‐propylnorapomorphine as an internal standard is described. The molecular ions of the TMS derivatives of apomorphine ( m/z 411) and N‐n ‐propylnorapomorphine ( m/z 439) were assayed simultaneously by selected ion monitoring. Sensitivity was 30 ng per ml plasma. The results obtained by a plasma apomorphine concentration time course study in rats suggested that this method was applicable to pharmacokinetic studies for apomorphine.