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Investigation of the urinary excretion of pethidine and five of its metabolites in man using selected ion monitoring
Author(s) -
Lindberg Claes,
Bondesson Ulf,
Hartvig Per
Publication year - 1980
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200070210
Subject(s) - pethidine , urine , excretion , chemistry , chromatography , urinary system , pharmacology , endocrinology , medicine , biochemistry , analgesic
The urinary excretion in man of pethidine and five of its metabolites (norpethidine, pethidinic acid, norpethidinic acid, p ‐hydroxypethidine and pethidine N ‐oxide) after a single intramuscular dose has been investigated using analytical procedures based on selected ion monitoring. New methods for the determination of p ‐hydroxypethidine and pethidine N ‐oxide have been developed, and the selectivity and sensitivity of the procedures are discussed. Only some 5% of the administered dose was excreted as unchanged pethidine. The mean urinary excretion of norpethidine was 16.4%. Pethidinic acid and norpethidinic acid constituted the major fraction of the dose excreted in urine. The total excretion of pethidinic acid and norpethidinic acid was 41.7 and 23.2%, respectively. Pethidine N ‐oxide constituted less than 0.5% of the excreted amount, and p ‐hydroxypethidine could only be detected in the urine of two of the patients. A mean total recovery of about 90% of the dose was found in urine as pethidine and the five metabolites.