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Specific quantitation of urinary 6‐hydroxymelatonin sulphate by gas chromatography mass spectrometry
Author(s) -
Fellenberg A. J.,
Phillipou G.,
Seamark R. F.
Publication year - 1980
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200070209
Subject(s) - mass spectrometry , chromatography , urinary system , metabolite , gas chromatography–mass spectrometry , gas chromatography , urine , chemistry , melatonin , biology , endocrinology , biochemistry
Abstract 6‐Hydroxymelatonin sulphate, a unique urinary metabolite of melatonin, has been measured in human subjects for the first time using as chromatography mass spectrometry and an isotope labelled internal standard. Urinary levels in both males and females were similar and ranged from 25‐125 nmol 24 h −1 . A significant nocturnal elevation of 6‐hydroxymelatonin sulphate was also established in a male subject.