N ‐acylglycines: Gas chromatographic mass spectrometric identification and determination in urine by selected ion monitoring | Zendy

Gregersen Niels | Zendy; Keiding Kristian | Zendy; Kølvraa Steen | Zendy

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N ‐acylglycines: Gas chromatographic mass spectrometric identification and determination in urine by selected ion monitoring

Author(s) -

Gregersen Niels,

Keiding Kristian,

Kølvraa Steen

Publication year - 1979

Publication title -

biomedical mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0306-042X

DOI - 10.1002/bms.1200061007

Subject(s) - trimethylsilyl , chromatography , chemistry , urine , selected ion monitoring , gas chromatography , ion , mass spectrometry , gas chromatography–mass spectrometry , organic chemistry , biochemistry

Eleven biologically interesting N ‐acylglycines have been synthesized and the gas chromatographic and mass spectrometric properties of their trimethylsilyl derivatives studied. A sharp and reproducible gas chromatographic peak could be obtained for each N ‐acylglycine as the N, O ‐bis‐(trimethylsilyl)‐ N ‐acylglycine. By the use of these derivatives a sensitive and specific selected ion monitoring method for the determination of N ‐acylglycines in human urine has been developed.

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