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N ‐acylglycines: Gas chromatographic mass spectrometric identification and determination in urine by selected ion monitoring
Author(s) -
Gregersen Niels,
Keiding Kristian,
Kølvraa Steen
Publication year - 1979
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200061007
Subject(s) - trimethylsilyl , chromatography , chemistry , urine , selected ion monitoring , gas chromatography , ion , mass spectrometry , gas chromatography–mass spectrometry , organic chemistry , biochemistry
Eleven biologically interesting N ‐acylglycines have been synthesized and the gas chromatographic and mass spectrometric properties of their trimethylsilyl derivatives studied. A sharp and reproducible gas chromatographic peak could be obtained for each N ‐acylglycine as the N, O ‐bis‐(trimethylsilyl)‐ N ‐acylglycine. By the use of these derivatives a sensitive and specific selected ion monitoring method for the determination of N ‐acylglycines in human urine has been developed.