Premium
A comparison of calculation procedures for isotope dilution determinations using gas chromatography mass spectrometry
Author(s) -
Colby B. N.,
McCaman M. W.
Publication year - 1979
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200060602
Subject(s) - isotope dilution , chemistry , mass spectrometry , isotope , chromatography , limiting , gas chromatography , analytical chemistry (journal) , isotope ratio mass spectrometry , gas chromatography–mass spectrometry , mole , organic chemistry , physics , mechanical engineering , quantum mechanics , engineering
Several data reduction procedures have been used for converting isotope ratios, determined using gas chromatography mass spectrometry, into mole ratios for the purpose of quantitating organic compounds. In this report, these procedures are shown to be related under certain limiting approximations of original sample and internal standard isotope ratios. With the understanding that some of the procedures involve approximations, the incorporation of related systematic errors into calculated mole ratio values was investigated. The results indicate that certain data reduction procedures allow quantitation over wider mole ratio ranges and with internal standards which contain a significant quantity of unlabeled impurity.