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Synthesis and mass spectrometry of deuterated methadone and methadone metabolites
Author(s) -
Kang Gun Ii,
Abbott Frank S.,
Burton Roland
Publication year - 1979
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200060502
Subject(s) - methadone , deuterium , chemistry , mass spectrometry , fragmentation (computing) , gas chromatography–mass spectrometry , pyrrolidine , chromatography , medicinal chemistry , pharmacology , medicine , physics , quantum mechanics , computer science , operating system
Deuterated methadone, 2‐ethylidene‐1,5‐dimethyl‐3,3‐diphenyl pyrrolidine, 2‐ethyl‐5‐methyl‐3,3‐diphenyl‐1‐pyrroline, 1,5‐dimethyl‐3,3‐diphenyl‐2‐pyrrolidone and 4‐dimethylamino‐2,2‐diphenylpentanoic acid have been synthesized for application to metabolic studies of methadone and as potential internal standards for selected ion monitoring methods. Mass fragmentation patterns are described based upon comparisons between labeled and unlabeled derivatives.