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Some new fluorescent derivatives for the mass spectrometric quantitation of biogenic amines
Author(s) -
Davis Bruce A.
Publication year - 1979
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200060404
Subject(s) - chemistry , mass spectrum , alkyl , ion , chromatography , mass spectrometry , fluorescence , sulfonyl , solvent , tyramine , selected ion monitoring , analytical chemistry (journal) , organic chemistry , gas chromatography–mass spectrometry , biochemistry , physics , quantum mechanics
The 5‐dimethyl‐, diethyl‐, dibutyl‐, and dipentyl‐aminonaphthalene‐1‐sulfonyl (dansyl, ethansyl, propansyl, bansyl and pentansyl resectively) derivatives of tyramine and other biogenic amines were prepared and their mass spectra recoded. The relative intensity of the largest unique ion increased with increasing length of the alkyl group. Several O ‐alkyl‐ N ‐propansyl‐ and N,O ‐dialkyl‐ N ‐propansyl‐, bansyl‐ and pentansyl‐tyramines were also synthesized and their mass spectra recorded. Dimethylbansyl‐ and dimethylpentansyltyramines exhibited the largest unique ions in their mass spectra and the greatest sensitivity in quantitation by the integrated ion current method. Procedures for preparing these derivatives in amounts ranging from nanograms to milligrams are presented and their thin‐layer chromatographic behavior in three solvent systems is described.