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Real‐time analysis of breath using an atmospheric pressure ionization mass spectrometer
Author(s) -
Lovett A. M.,
Reid N. M.,
Buckley J. A.,
French J. B.,
Cameron D. M.
Publication year - 1979
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200060302
Subject(s) - atmospheric pressure chemical ionization , mass spectrometry , breath gas analysis , chemical ionization , atmospheric pressure , chemistry , ionization , ambient ionization , spectrometer , analytical chemistry (journal) , dart ion source , desorption electrospray ionization , chromatography , physics , optics , ion , electron ionization , meteorology , organic chemistry
A new technique is reported resulting in the direct, instantaneous analyses of trace compounds in breath. The analyses were performed using a commercial atmospheric pressure chemical ionization mass spectrometer (TAGA TM 2000 APCI mass spectrometer). A known flow of breath sample is introduced into the ionization region of the mass spectrometer. The study includes the measurement and monitoring in real‐time, of breath ammonia during a 24 hour and a 48 hour period. The ammonia profiles indicate a personalized daily pattern associated with each subject. This method appears to be of potential value in routine detection and treatment of hyperammonemia patients. Results also show that it is possible to obtain instantaneous analyses of several naturally occurring metabolites and other substances on breath in the ppm to ppt range, suggesting a number of diagnostic research applications.